Mandrake BioTissue-culture-free elite crop editing
Editors designed to work directly in elite plant tissue to dramatically shorten gene-editing timelines by up to 80%
The first generation
of gene editors
was discoveredThe next will
be designed from
the function up
A full-stack protein-design company building the molecular machinery for next-generation gene editing We design systems from scratch, around the function each application demands, rather than optimising enzymes that already exist
Read the thesisFunction built into the design
Rather than random generation, we encode each application's biological and biophysical requirements directly into our models, then validate function through purpose-built assays, and every result feeds the next design round, already producing double-digit experimental hit rates
Mandrake Terrabase
On-prem, interconnected DNA-protein data with rich biological context
0genomes
0Tbp
Function-aware generation
Proprietary sequence- and structure-aware models, post-trained on custom biological context and data
Generative AI
Bio Physics
Purpose-built assays
Functional testing in our in-house wet lab and partner network
Our next-generation editors will enable breakthrough applications
In vivo Gene Therapies
Editors designed around delivery from the start, enabling lower doses, simpler delivery and more accessible genetic medicines
Research, results and open science
More results publishing soonRBX1: the only design rated Strong
12,000+ designs submitted One Strong design 26 nM binding affinity
Read
The Assay
Challenges & Fellowship
Press & announcements
Let's make life programmable
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